为提升 L-DOPA 产量,研究人员对长柄萼距花细胞培养物开展研究,发现前体诱导可增产,具商业潜力。 长柄萼距花(Hybanthus enneaspermus (L.) F.Muell.)因具有产生左旋多巴(L-Dopa)的潜力而在医学领域备受关注。本研究旨在探索通过前体添加诱导长柄萼距花细胞培养 ...
为解决帕金森病治疗评估难题,研究人员用 DFA 和香农熵研究患者震颤,发现其可反映治疗影响,助力病情分析。 不同条件下的香农熵结果 :当 L-dopa 和 DBS 均关闭时,高振幅震颤组的香农熵均值约为 0.93,接近最大值 1.0(代表最大不确定性),低振幅震颤组约为 0.61。随着 DBS 或 L-dopa 开启,高振幅震颤组的香农熵值降低,逐渐接近低振幅震颤组。当 DBS 和 L-dopa ...
Previous studies in a rat model of Parkinson disease (PD) have shown that dyskinesia induced by L-DOPA—a treatment-limiting adverse effect of long-term administration—is caused by the release ...
L-DOPA is a dopamine precursor molecule often used to treat Parkinson's disease because it can enter the brain from the blood, where it is then converted into dopamine.
We have shown that L-DOPA treatment can help reduce harmful beta-amyloid plaques and improve memory function in a mouse model of Alzheimer's disease.