Notch needs to cooperate with oncoproteins that can override the G1–S checkpoint in order to cause cancer. Notch receptors and ligands are re-expressed in certain human carcinomas, which is ...

This may have important consequences for tumorigenesis but the exact role of Notch genes in cancer development is not known. In September 1 Genes and Development Claudio Talora and colleagues from ...

A cell signaling mechanism of fundamental importance to animal development is the Notch pathway (Figure 1). It may be safely said that Notch signaling is required, in some reasonably direct fashion, ...

This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

This review highlights the critical role of ubiquitination in governing the functionality of cancer stem cells (CSCs), ...