most notably the phosphoinositide 3-kinase (PI3K) enzymes. The lipids generated by these kinases in response to receptor stimulation are asymmetrically distributed in the membranes of chemotaxing ...

The current PI3K 3C inhibitors in use in advanced breast cancer are alpelisib and inavolisib. Capivasertib is an AKT inhibitor, which is also used in PI3K 3C mutated breast cancer. So these are ...

The activity of the PI3K complex is controlled by the ULK1 complex ... The team identified ZDHHC13, a palmitoylation enzyme, ...