Eledon Pharmaceuticals, Inc. (“Eledon”) (Nasdaq: ELDN) today announced that Steve Perrin, Ph.D., Chief Scientific Officer and President, will participate in a fireside chat at the upcoming Leerink ...

This trial demonstrates that next-generation CD40L blocking antibodies can be used safely in HCT recipients ... Keeping in mind that CD40 Ligand-CD40 interaction pathway is involved in T-cell ...

1 Department of Internal Medicine, Catholic University, Rome, Italy, and Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, ...

CD40 agonistic antibodies mimic the natural interaction between the CD40 receptor and its ligand, CD40L, triggering immune responses through cytokine release and T-cell activation.

CONCLUSIONS Both CD40L/CD154 on platelets and soluble CD40L/CD154 are raised in patients with unstable angina and myocardial infarction. These findings suggest that CD40–CD40L/CD154 interactions may ...

Introduction: B-cell activation triggers the release of endoplasmic reticulum calcium stores through the store-operated calcium entry (SOCE) pathway resulting in calcium influx by calcium ...

Feb. 26, 2025 — Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice ...

The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China Clinical Cancer Institute of Nanjing University, ...

We developed novel and unique anti-CD30 x anti-CD3 biAbs that trigger T cell-mediated activation and elimination of CD30-expressing tumor cells ... and OCIAML2 cells the multiplex panel included CD40L ...