Metoprolol is used for phenotyping of cytochrome P450 (CYP) 2D6 ... showing non-linearity after 4 min of incubation due to substrate depletion. Midazolam 1′-hydroxylation could almost completely be ...

This review summarizes the functions, structures of fungal CYP51 proteins, and the inhibitors targeting ... CYP51 proteins belong to the CYP superfamily and is the most conserved protein in it. Unlike ...

is a substrate of cytochrome P450 (CYP)2C8, CYP2C9, and CYP3A4, and to a minor extent, CYP2C19 and CYP2J2. ETR has the potential for drug-drug interaction (DDI) with CYP2C8, CYP2C9, and CYP3A4 when ...

Age-related changes in pharmacokinetics and pharmacodynamics may cause an increase in adverse drug reactions in elderly persons. Geriatric patients frequently have medical conditions such as ...

Psychoses are major mental disorders marked by derangement of personality and loss of contact with reality, and are common in the elderly. Various hypotheses suggest the pivotal role of abnormal ...

Here we present cryo-EM structures of lipid-embedded human ABCB1 in conformationally distinct apo-, substrate-bound, inhibitor-bound, and nucleotide-trapped states at 3.4–3.9 Å resolution, in the ...

As discussed below, discovery efforts for new inhibitors have typically been based on the structure of known protease substrates, presenting a substantial challenge for the development of ...

(Spoiler: It is.) While generic sildenafil and Viagra are equally safe and effective phosphodiesterase type 5 (PDE5) inhibitors, they have one key difference: price. Viagra costs $90 to $139 per ...

The manuscript represents a fundamental advance in designing peptide inhibitors targeting Cdc20, a key activator and substrate-recognition subunit of the APC/C ubiquitin ligase. Supported by ...