A pivotal study has uncovered that iron orchestrates the activation of two damaging cell death pathways—ferroptosis and ...

Cell death, a programmed cellular response to external harmful stimuli, including ferroptosis—a recently identified form of iron-dependent programmed cell death—emerges as a pivotal process.

Inhibitors of apoptosis, ferroptosis and other cell death mechanisms had no effect on this process, suggesting disulfidptosis is a distinct pathway. The discovery of disulfidptosis offers a new ...

122 The pathogenesis of doxorubicin-induced cardiotoxicity involves a complex process, including mitochondrial damage, oxidative stress, the inflammatory response, iron and calcium overload, ...