The single-cell analysis revealed a diverse range of cell types within the tumor microenvironment (TME), including tumor cells, immune cells, and fibroblasts, with varying proportions across cases.

For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient's response to CAR T cell therapy in real time. The ...

Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...

Squamous cell carcinoma (SCC) in the lung is one form of non-small cell lung cancer. Non-small cell lung cancers account for about 85% of lung cancers, many of them associated with smoking. Of these, ...

Fortunately, the prognosis for these tumors has improved.. It is important to differentiate aggressive and indolent tumors as the optimal treatments and well as prognosis differ considerably: ...

Scientists push CAR T cell therapy beyond blood cancers, unlocking potential for targeting solid tumors with enhanced delivery, resilience, and precision in the face of tough obstacles.

Tumors are the result of abnormal cell growth. Usually, the cells in your body grow and divide to form new cells whenever your body needs them. When older cells die, they’re replaced by new ones.

Introduction: T cell Antigen Coupler (TAC) T cells harness all signaling subunits of endogenous T cell receptor (TCR) to trigger T-cell activation and tumor cell lysis, with minimal release of ...