toxic hepatitis produced by psychotropic agents and alcohol-related liver disease, including cirrhosis, at daily doses ranging from 280 to 800mg, equivalent to 400 to 1140mg of standardised extract.
Other experiments to assess the acute toxicity of silymarin were performed in beagle dogs, rabbits, Wistar rats and NMRI mice after an intravenous bolus dose. Silymarin was used as the ...