Methods We compared Treg cells of patients with juvenile idiopathic arthritis responding or not to therapy by using: (i) T cell receptor (TCR) sequencing, to identify clonotypes shared between blood ...

Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM.

Synovial fibroblasts are mesenchymal cells recognized as a key cell population in RA due to their hyperproliferative and hypersensitive properties in the inflammatory milieu and hyperproduction of ...

SSG was injected with single drug into pleural effusion, pleural fluid samples were taken ... and the proportion of changes in immune cells before and after treatment. Through comparative analysis of ...

Methods SFs from 38 gouty patients were analysed for white blood cell (WBC) count, percentage of polymorphonuclear cells (PMNs) and levels of interleukin 1β (IL-1β), IL-6, IL-8, tumour necrosis ...

Therefore, this study employed a unique approach to examine the cell phenotype of clonally derived synovial MSCs obtained directly from synovial tissue (without an initial cell culture step). We have: ...

Our vision of cancer and tumors has been evolving with time, from the simplistic bunch of all-similar malignant cells to a more sophisticated, heterogeneous and hierarchical cellular structure ...

Jan. 17, 2025 — A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer ...

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...