Many ECs harbor mutations in cell cycle regulatory genes including TP53 and RB1, amongst others. RB and p53 both regulate the G1/S transition while p53 also regulates the G2/M transition and mitotic ...

stimulating p53 at frequencies that result in increased DNA repair gene expression and better maintenance of cell cycle arrest can aid in better recovery of cells in cases such as damage due to ...

p53 can activate JAK/STAT, and P21 expression is mediated by JAK/STAT activation ... Current evidence links CD133 to the regulation of cell cycle dynamics and therapy resistance, particularly in radio ...

Ubiquitin-specific protease 7 (USP7) is involved in DNA repair and cell cycle progression and, due to its control over the ubiquitination of key proteins, may impact oncogenes like MDM2 and c-Myc, as ...

leading to stabilization of p53, TP53 target gene induction, cell-cycle arrest and apoptosis in tumour cells with wild-type TP53 status. Activation of p53 also promotes an anti-tumour immune ...

Colon cancer continues to be one of the leading causes of cancer-related deaths worldwide, with poor dietary habits ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...

In a nutshell Researchers discovered that a protein called AP2A1 acts as a master switch controlling whether cells behave young or old When scientists reduced AP2A1 levels in aged cells, they showed ...

A new study has revealed that ferulic acid, a natural compound found in various plant-based foods, can significantly inhibit the growth and migration of colon cancer cells at different stages of ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in ... How Healthy Stem Cells Turn Into Or ...