Linkage analysis was originally used to identify familial Paget disease genes. One study indicated that about 29% of families with a history of Paget disease have a mutation in the sequestosome 1 ...

New research shows that intensive bisphosphonate therapy for Paget disease of bone has no beneficial effect on quality of life, bone pain or clinical complications compared with symptomatic ...

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Paget disease often presents as a rare asymptomatic lesion of the bone until it progresses into the advanced stages. A senile man was diagnosed with Paget disease of bone on routine dental ...

Although abundant evidence of concomitant cardiovascular disease is scattered throughout the literature on osteitis deformans, appreciation of the etiologic relationship between the two diseases has ...

June 10, 2024 — Scientists have grown 'mini-guts' in the lab to help understand Crohn's disease, showing that 'switches' that modify DNA in gut cells play an ... Major Cause of Inflammatory ...

7, 2025 — People who drink coffee in the morning have a lower risk of dying from cardiovascular disease and a lower overall mortality risk compared to all-day coffee drinkers, according to new ...

There is evidence that Crohn’s disease is genetic, though environmental factors may also be involved. Crohn’s disease is a type of inflammatory bowel disease (IBD) that causes inflammation in ...

Inflammatory bowel disease (IBD) is a group of intestinal disorders that cause prolonged inflammation of the digestive tract. It can include ulcerative colitis (UC) or Crohn’s disease.

Crohn's disease is a chronic inflammatory bowel disease that primarily affects the gastrointestinal tract but can affect other organs in the body too. Crohn's disease symptoms that involve ...