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Nature: C末端酰胺修饰 为蛋白质降解提供临床治疗的新武器
近年来,研究人员发现了一种新的蛋白质降解信号——C末端酰胺(C-terminal amides)。这种特殊的化学标记,在蛋白质末端形成一种独特的酰胺基团,使得这些蛋白质成为细胞降解系统的靶标。这一发现为我们揭示了细胞如何通过非传统的方式识别和处理受损蛋白质,尤其是在氧化应激等压力条件下的蛋白质损伤。
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