Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, United States The receptor tyrosine ... intracellular VEGFR3 tyrosine kinase ...

Erythropoietin-producing hepatoma (Eph) receptors, including EphA4, are expressed on the cell surface and involved in brain development, which involves extensive pruning of synapses. A variant in ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

Generalized myasthenia gravis (gMG) affects most patients through a handful of well-characterized neuromuscular junction ...

4 PAM signaling pathway associated with targeted therapy The PAM signaling pathway ... A phase I study investigated the combination of MK-2206 and gefitinib in NSCLC patients who failed prior ...

This useful study presents findings on the developmental roles of Nup107, a key nucleoporin, in regulating the larval-to-pupal transition in Drosophila melanogaster through its involvement in ecdysone ...

The latter is known as tyrosine kinase ... Promiscuous Janus kinase binding to cytokine receptors modulates signaling efficiencies and contributes to cytokine pleiotropy, Science Signaling ...

Laboratory of Protein Engineering and Bioinformatics (PROTEP), Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand Department of Clinical Chemistry, Faculty ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

Discover a study that describes a host-intrinsic mechanism responsible for the failure of PD-L1 blockade in ovarian cancer.