HU inhibits ribonucleotide reductase and thereby dramatically slows S phase ... the displaced helicase complex is significantly more prone to activation than its non-displaced counterpart. Moreover, ...

Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

In addition raised dATP inhibits ribonucleotide reductase which is necessary for normal DNA synthesis. Because of the high turnover of lymphocytes, the highest amount of ADA expression is found in ...

Ultimately, pelareorep infusion induced APC stimulation and activation of T cells, suggesting that pelareorep could initiate antitumor and pro-inflammatory immune response (105). Similarly, a phase Ib ...

This valuable study is a detailed investigation of how chromatin structure influences replication origin function in yeast ribosomal DNA, with a focus on the role of the histone deacetylase Sir2 and ...

Especially, PKR is one of four kinases that integrate stress responses. It regulates the protein homeostasis of the cell to maintain the body’s homeostasis; conversely, its abnormal activation can ...

Compiled for Windows x86 (Win32) using MSVC++ v14.29 in Visual Studios 2019 .NET Framework 4.0 and Windows SDK 10.22000.0.

Department of Chemistry, University of California Davis, Davis, California 95616, United States ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The DNA-damaging agent Gemcitabine (GEM) is a ...

1 Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Sheffield, UK 2 Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Sheffield, UK 3 Gastroenterology Unit, John ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Homologous recombination (HR) is important for ...