Indeed, several drugs targeting histone modifications are in clinical use or undergoing clinical trials. Acyl-lysine histone modifications (e.g. methylation, acetylation, and crotonylation) have ...

The most popular of these treatments aim to alter either DNA methylation or histone acetylation. Inhibitors of DNA methylation can reactivate genes that have been silenced. Two examples of these ...

Histone H3 and H4 acetylation was increased in the striatum following phenylbutyrate treatment, and there was a decrease in methylation of histone H3. Microarray analysis of the phenylbutyrate ...

DNA methylation is mediated by the enzyme DNA methyltransferase (DNMT), which transfers methyl groups to adenine (A), guanine (G), or cytosine (C) by using S-adenosyl methionine (SAM) as a substrate.

Telegram may be among the most popular messaging services in the world, yet many still don’t know what it’s all about. The app is often name-dropped in discussions regarding online privacy and ...

Artificial Intelligence - two words that spark equal parts excitement and existential dread. But what exactly is AI? Is it the unseen force behind your eerily well-timed online ads? The chatbot ...

The 'i' in Apple products like iPhone and iMac stands for internet, individual, instruct, inform, and inspire. Introduced by Steve Jobs in 1998, it embodies Apple's vision of connectivity ...

These useful findings assigned a novel functional implication of histone acylation, crotonylation. Although the mechanistic insights have been provided in great detail regarding the role of the YEATS2 ...

Adam Hayes, Ph.D., CFA, is a financial writer with 15+ years Wall Street experience as a derivatives trader. Besides his extensive derivative trading expertise, Adam is an expert in economics and ...

SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...