A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

This month's cover highlights the article Immune cells adapt to confined environments in vivo to optimise nuclear plasticity for migration by Helen Weavers and Tua Karling. The cover features confocal ...

ICP22 condensates depleted the serine-2 phosphorylated RNA polymerase II (RNAPII Ser-2P) occupancy from the host transcription start site ... These condensates are responsible for the loss of promoter ...

SNPs associated with Parkinson’s disease and schizophrenia are enriched in enhancers active in LUHMES cells. We identify enhancer–promoter interactions via the Capture Hi-C method and functionally ...

Various non-coding RNAs (ncRNAs) account for the majority of total RNA in cells and have an important regulatory role in myogenesis. In this review, we introduced the research progress in miRNAs, ...

Errors during transcription may play an important role in determining cellular phenotypes: the RNA polymerase error rate is >4 orders of magnitude higher than that of ...