Fortunately, the phenotypic correlations can be estimated based on established GWAS summary statistics, especially when the proportion of sample overlap between two GWASed phenotypes is large. Two ...

Learn about our editorial policies A negative, or inverse correlation, between two variables, indicates that one variable increases while the other decreases, and vice versa. This relationship may ...

As the GWAS database that was used contained multiple different GWAS for certain traits ... This finding persists in models assuming both very high (0.9) and low (0.1) phenotypic correlation. With ...

using the GWAS summary statistics from the GIANT consortium as an example, and try to replicate them in the UK Biobank (UKB). We performed a series of simulations to compare the replication results of ...

Genome-wide association studies (GWAS) have been widely employed to identify genetic variants that are associated with risk for disease and physiologically relevant traits (Tam et al., 2019; Visscher ...