FGFR signaling plays a role in angiogenesis, tumor cell migration, differentiation, proliferation and survival (13). IDH1 R132H mutations, while very common in adult lower-grade gliomas, are extremely ...

Taken collectively, these recent advances in producing genetically faithful GEMMs of IDH1 mutant glioma open new avenues to explore how this oncogene promotes gliomagenesis and creates therapeutic ...

Most types of cancers are made up of heterogeneous mixtures of genetically distinct subclones. In particular, acute myeloid leukemia (AML) has been shown to undergo substantial clonal evolution ...