Here, the authors report thiazolyl ketone inhibitors of cPLA2α starting from compound GK470 (AVX235), and the discovery of a more potent and selective lead, GK420 (AVX420), with significant ...

a TechBio that uses agentic AI to unlock complex targets for drug discovery ... support our internal development programs, including for the manufacture and supply of preclinical and clinical ...

Data showing continued in vitro neutralizing activity of PEMGARDA™ (pemivibart) against XEC have been submitted to the U.S. Food and Drug Administration (FDA), with a timely ... the timing and ...

VANCOUVER, British Columbia, Jan. 06, 2025 (GLOBE NEWSWIRE) -- Rakovina Therapeutics Inc. (TSX-V: RKV), a biopharmaceutical company focused on the development of new cancer therapies based on novel ...

In this study, we addressed the impending need for a preclinical screening model resembling the physiology of a human atrial cardiomyocyte. The finding that hESC‐atrial CMs are a robust model for ...

An investigational drug for multiple sclerosis from Io Therapeutics has restored leg mobility and myelin nerve coatings in mice, the biotech announced Dec. 23. The Texas-based company conducted ...

“We are disappointed by the results from KOASTAL-1 as they were not consistent with the body of evidence supporting this mechanism in MDD,” Rob Lenz, executive vice president and head of research and ...

Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology. Targeted ...

An airplane drops fire retardant as firefighters battle Franklin fire on Dec. 10 in Malibu. (Brian van der Brug / Los Angeles Times) ...

It also utilizes an In-house systemic platform. The company operates a drug research and development center that covers early discovery, preclinical research, IND, clinical research, biologics license ...

Chemical Research Laboratories, Japan Tobacco, Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan ...

The Mystery King’s son, Miguel Aaron Lopez Hernandez, better known as El Hijo de Rey Misterio was once arrested on drug charges. In May 2012, Hernandez and his younger brother were arrested in ...