"Our research spans innovative therapeutic solutions such as Mazindol ER for fentanyl dependence, dual orexin receptor agonists for narcolepsy, and a multitarget approach to managing diabetes ...

Eric Konofal, MD, PhD, Chief Scientific Officer of NLS Pharmaceutics. "Our research spans innovative therapeutic solutions such as Mazindol ER for fentanyl dependence, dual orexin receptor agonists ...

Mazindol ER is patent protected beyond September ... potentially reducing cravings and withdrawal symptoms without reinforcing addiction. Orexin-2 receptor ("OX2R") partial agonist: Aids in ...

You have permission to edit this article. Edit Close Activate Subscribe My Account Logout Login/Register ...

Provided herein are novel urea-containing compounds as orexin receptor agonists, pharmaceutical compositions, use of such compounds in treating sleep disorders, namely, narcolepsy, hypersomnia, and ...

Orexin receptor activation has been documented to result in an enormously varied set of downstream interactions, involving many key cascades within the signaling milieu. Studies investigating ...