By contrast, synovial fluid neutrophils exhibited more than 1600 differentially expressed genes. Gene signatures identified a prominent response to interferon gamma (IFN-γ), as well as to tumour ...

11 Calgranulin A (S100A8) and calgranulin B (S100A9) are secreted following cellular activation or necrosis, have antimicrobial activity, and can induce neutrophil chemotaxis and adhesion.

The impact of Card9 deletion on neutrophil function was assessed by an in vivo model of fungal infection and various functional assays, including endpoint dilution assay, apoptosis assay by flow ...

Graduate School of Life Science and System Engineering, Kyushu Institute of Technology, 2-4, Hibikino, Wakamatsu, 808-0196 Kitakyushu, Japan ...

3 Jiangxi Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Nanchang, People's Republic of China 4 Key Laboratory of Rheumatology and Immunology, Health Commission of Jiangxi ...

State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan ...

This important study provides compelling evidence that CCL28 plays a crucial role in regulating neutrophil function and host defense during mucosal infections, with CCL28 deficiency leading to greater ...

On the other side, neutrophils also infiltrate the TME through chP under the attraction of CXCL1/2. In the TME, TANs are predominantly found in the central necrotic zone, while TAMs tend to accumulate ...

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This may also impact the localization and agonistic activity of the formyl-peptides in vivo. It is clear that LTB4 is an essential necrotic “find-me” signal to neutrophils. Yet, many questions ...