2023年7月21日 · In Japan and Europe, a B12 level of 500 to 550 picograms per milliliter is recognized as associated with memory loss, attention deficit disorder, and cognitive decline, especially in children (who may not have lived long enough for their livers to store enough B12) and the elderly (who can have digestive disorders than keep their stomachs from ...

2022年11月3日 · As a matter of fact, Japan raised its B12 reference range to 500 – 1300 Pmol in 1980s. These phenomena raise some questions to us: Is the current reference range or normal lower limit of B12 set too low? What level should be set as the lower limit of B12 reference range?

The medical field in Japan and Europe considers a patient to have vitamin B12 deficiency if testing reveals levels below 500 pg/mL to 550 pg/mL. Meanwhile, the low end of “normal” in America is 200pg/mL to 350 pg/mL.

Most cyanobacteria, including Spirulina, and some algae, such as Porphyra tenera (used to make a dried seaweed food called nori in Japan), have been found to contain mostly pseudovitamin-B 12 instead of biologically active B 12.

2011年5月6日 · B12 deficiency can mimic the signs of Alzheimer’s, dementia, multiple sclerosis, and several mental illnesses. Find out what this vitamin does and learn how to treat a deficiency. #B12 #B12deficiency #cognitivedecline. In Japan and Europe, the lower limit for B12 is between 500 and 550 pg/mL.

2023年1月18日 · Japan’s low normal for B12, for instance, was 500-550 because at lower levels dementia and memory loss appear. Conversely, in the U.S. the low normal is 200 pmol/mL, the level at which blood abnormalities begin to appear. (Sadly, Japan has since lowered its level.)

2022年12月20日 · The often mentioned Japanese reference range for B12 seems to be stemming from this 1988 study: Mitsuyama Y, Kogoh H. Serum and cerebrospinal fluid vitamin B12 levels in demented patients with CH3-B12 treatment--preliminary study. Jpn J Psychiatry Neurol. 1988. The abstract mentions a range of 500-1,300 pg/ml.

In America, B12 deficiency is evidenced as a serum level below 200 pg/ml (145 pM). In Japan, a deficiency is found in levels under 550 pg/ml (400pM). Most B12 researchers and advanced functional nutritionists agree with the Japanese model.

In most countries, the lower vitamin B12 range of what’s considered normal levels is too low (100-250), often missing severe deficiencies. People show signs of B12 deficiency even at higher levels, as deficiencies may begin to appear in the cerebrospinal fluid below 550.

Currently 12 vitamins (A, 81, 82, B6, B12, C, D, E, Niacin, Folic Acid, Biotin and Pantothenic Acid) plus 2 minerals (Ca, Fe) have been placed in this group. Permissible nutrition claims for these items are listed in Appendix 1 of this report.