2019年7月31日 · Here, using forward genetic screening with targeted genome editing, we have identified a unique domain in the N-terminus that is critical for its in vivo function. Additionally, we characterized three nuclear localization signals (NLS) in CEBP-1 that act together to mediate CEBP-1's nuclear import.

2006年9月25日 · Our studies also revealed that the overall structural features of full-length HY5 are dominated largely by the disordered N-terminal domain, despite the existence of a bZIP domain at its C-terminus. We propose that HY5 is a member of the intrinsically unstructured protein (IUP) family, and that HY5 functions as an unstructured protein and ...

2023年6月10日 · The C-terminal zipper regions of the two subunits can combine to form a homodimer or heterodimer through the hydrophobic side of the helix. The bZIP transcription activation domain is rich in proline, glutamine, or acidic amino acids (Jakoby et al. 2002).

2019年7月30日 · CEBP-1 consists of a canonical bZIP domain at the C-terminus, with a long N-terminal region having no known protein motifs. Here, through forward genetic analyses, we have identified a stretch of 15 amino acids at the N-terminus of CEBP-1 that is critical for its in vivo function and axon regeneration.

CEBP-1 consists of a canonical bZIP domain at the C-terminus, with a long N-terminal region having no known protein motifs. Here, through forward genetic analyses, we have identified a stretch of 15 amino acids at the N-terminus of CEBP-1 that is critical for its in vivo function and axon regeneration.

2014年3月2日 · There are six CEBP proteins in mammalian cells including CEBPA (alpha), CEBPB (beta), CEBPG (gamma), CEBPD (delta), and CEBPE (epsilon), which all contain highly conserved bZIP domains at their C-termini and variations at their N-terminal regions. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of ...

2002年3月1日 · In plants, basic region/leucine zipper motif (bZIP) transcription factors regulate processes including pathogen defence, light and stress signalling, seed maturation and flower development. The Arabidopsis genome sequence contains 75 distinct members of the bZIP family, of which ∼50 are not described in the literature.

2002年3月1日 · In plants, basic region/leucine zipper motif (bZIP) transcription factors regulate processes including pathogen defence, light and stress signalling, seed maturation and flower development. The Arabidopsis genome sequence contains 75 distinct members of the bZIP family, of which ∼50 are not described in the literature.

Basic leucine zipper (bZIP) proteins constitute one of the largest TF families in plants. These TFs are characterized by a conserved bZIP domain that contains a N-terminus DNA binding region with an affinity for ACGT-containing elements and a leucine zipper region for dimerization at the C-terminus (Fernando, 2020; Wang et al., 2021a, b). In ...

2006年1月1日 · The N-terminal half contains basic amino acid residues that interact with the major groove of DNA in a sequence-specific manner. The C-terminal half is a leucine zipper—an amphipathic α-helix that dimerizes to generate a parallel coiled-coil.