CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells.

CD45 is a type of protein called a tyrosine phosphatase. It plays a critical role in regulating cell signaling pathways that are important for immune cell activation and differentiation. How is CD45 used in pathology?

CD45, also named protein tyrosine phosphatase receptor type C (PTPRC), is the leukocyte common antigen (Rheinlander et al., 2018). It is expressed on almost all cells of the immunological and hematological systems except for mature erythrocytes and platelets (Barford et …

CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and …

2018年4月1日 · CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively expressed on all nucleated cells of the hematopoietic system. It is characterized by the expression of several isoforms, specific to a certain cell type and the developmental or activation status of the cell.

CD45 is an essential protein on the surface of cells of the haematological and immunological systems. It has been used as a diagnostic tool to identify cells of haematological origin, but its function and structure are not widely understood. This review aims to …

CD45 activates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts.

CD45 has been recognized as an important player in regulating signalling in lymphocytes. However, compared with tyrosine kinases, phosphatases are still poorly understood in terms of the details of their specificity and regulation. Here, the recent ...

CD45 is a major transmembrane glycoprotein expressed on all nucleated hematopoietic cells. Eight isoforms of CD45 are distributed through the immune system according to cell type and degree of cellular differentiation.

2024年12月25日 · PTPRC (Protein Tyrosine Phosphatase Receptor Type C) is a Protein Coding gene. Diseases associated with PTPRC include Immunodeficiency 105, Severe Combined and Immunodeficiency 104, Severe Combined. Among its related pathways are Activation of cAMP-Dependent PKA and Innate Immune System.