The NCI Common Terminology Criteria for Adverse Events is a descriptive terminology which can be utilized for Adverse Event (AE) reporting. A grading (severity) scale is provided for each AE term.

Drug-induced ototoxicity should be distinguished from age-related threshold decrements or unrelated cochlear insult. When considering whether an adverse event has occurred, it is first necessary to classify the patient into one of two groups.

In a comparison between outcomes of four ototoxicity scales in 319 adult patients treated with chemo-radiation or radiation therapy alone for head and neck cancer, the prevalence of ototoxicity was rank ordered, lowest to highest, as CTCAE v4.0, ASHA up to 8 kHz, TUNE, and ASHA up to 12.5 kHz (Theunissen et al. 2014). As expected, scales that ...

2010年3月1日 · Clinical trials report ototoxicity as an adverse event based on a numeric grading system, the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE). 4 The CTCAE criteria assign grades of 1, 2, 3, or 4 for chemotherapy-induced hearing loss and combine subjective hearing loss assessment with objective threshold shifts ...

2011年12月1日 · Pure-tone audiograms were evaluated using the newly proposed grading criteria, Brock criteria, and Common Terminology Criteria for Adverse Events (CTCAE). The resulting grades were then...

According to the most recent version of the NCI CTCAE (version 5.0), hearing loss is graded differently for children versus adults, on a scale of Grade 1 to Grade 4. There is no Grade 5 hearing loss, as death is not considered a possible outcome from hearing loss. In children, Grades 1 to 4 are defined in Table 1 . Table 1.

2010年4月1日 · This grading system provides robust and clinically useful criteria to represent clinical hearing loss induced by ototoxicity with regard to the impact on speech and language and the need for assistive hearing devices. It is both more specific and more sensitive than the traditional CTCAE criteria fo …

Pure-tone audiograms were evaluated using the newly proposed grading criteria, Brock criteria, and Common Terminology Criteria for Adverse Events (CTCAE). The resulting grades were then compared to recommended audiologic interventions.

Although widely used, the CTCAE criteria do not include HFA, which, as previously discussed, can be very useful in the early detection of ototoxicity. Additionally, the CTCAE criteria include some subjective measures, such as determining if intervention is required, which can cause comparisons across studies or across clinics to be imprecise ...

2011年11月22日 · Pure-tone audiograms were evaluated using the newly proposed grading criteria, Brock criteria, and Common Terminology Criteria for Adverse Events (CTCAE). The resulting grades were then compared to recommended audiologic interventions.