Cobblestone degeneration, also known as pavingstone degeneration, is a common, benign condition that affects the peripheral retina. It typically occurs naturally as part of the aging process and rarely causes any vision problems.

Key Differences Between Pavingstone and Cobblestone Degeneration. Location: Both primarily affect the peripheral retina. Origin: Pavingstone degeneration is often age-related, while cobblestone degeneration is usually congenital. Appearance: Pavingstone presents as flat, yellow-white patches; cobblestone appears as small holes.

2020年3月24日 · Pavingstone (cobblestone) degeneration is a peripheral retinal degeneration characterized by multiple rounded, punched-out areas of chorioretinal atrophy with prominent underlying choroidal vessels and pigmented borders ( Fig. 44.1). Lesions are yellow–white regions of depigmentation caused by chorioretinal atrophy, which can occur singly or ...

Characteristics: either retinal tear or retinal hole, retinal holes due to atrophic changes in neurosensory retina; Complications: high risk of rhegmatogenous retinal detachment, occurs in 3-18% of patients

2021年2月15日 · Peripheral drusen and peripheral reticular degeneration (PRD) are common and often underreported peripheral retinal findings that can be seen in patients with or without macular degeneration. Although these are both related to age, they are two distinct conditions with two different phenotypes and should be treated as such.

2024年8月26日 · Cobblestone degeneration (also known as pavingstone degeneration) presents as yellow-white patches resembling cobblestones in the peripheral retina. It is commonly observed in aging eyes and high myopia. Diagnosis is made through clinical examination with fundus imaging. Generally, intervention is unnecessary. 5.

鹅卵石视网膜病变，又称铺路石视网膜病变，与炎症性脂溢性角化病和胸腺瘤B2型有关。 与鹅卵石视网膜病变有关的重要基因是BANF1（BAF核装配因子1），其相关通路/超级通路包括先天免疫系统和传染病。 附属组织包括视网膜，相关表型为shRNA丰度增加（Z-score>2）和正常。 该模块正在开发中，请耐心等待我们的数据更新。 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). 鹅卵石视网膜病变，又称铺路石 …

2021年5月6日 · Peripheral cobblestone regions in highly myopic eyes are characterized by marked BM thinning with absence of an inner BM layer, almost complete RPE absence, choriocapillaris thinning and firm connection of a disorganized retina to BM. These findings may help elucidating the process of axial elongation in myopic eyes.

Integrated disease information for Cobblestone Retinal Degeneration including associated genes, mutations, phenotypes, pathways, drugs, and more - integrated from 77 data sources

Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level.