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Endoplasmic reticulum stress: molecular mechanism and
2023年9月15日 · ER stress activates an adaptive unfolded protein response to restore proteostasis by initiating protein kinase R-like ER kinase, activating transcription factor 6, and …
The unfolded protein response: controlling cell fate decisions under ER …
2012年1月18日 · ER stress is buffered by the activation of the unfolded protein response (UPR), a homeostatic signalling network that orchestrates the recovery of ER function, and failure to …
Endoplasmic reticulum stress signalling – from basic …
In response to ER stress, cells trigger an adaptive signalling pathway called the unfolded protein response (UPR), which acts to help cells to cope with the stress by attenuating protein …
Endoplasmic Reticulum Stress in Disease Pathogenesis - PMC
ER stress occurs when the capacity of the ER to fold proteins becomes saturated. ER stress may be caused by factors that impair protein glycosylation or disulfide bond formation, or by …
The endoplasmic reticulum: structure, function and response …
How ER stress response pathways play a role in these pathologies is an active area of research and various components of the stress response pathways are being investigated as potential …
Endoplasmic Reticulum Stress - an overview - ScienceDirect
The endoplasmic reticulum (ER) stress refers to a condition that unfolded proteins accumulation in ER in response to stimuli such as oxidative stress, metabolic and ischemic insult. ER stress …
Endoplasmic Reticulum Stress - an overview - ScienceDirect
Endoplasmic reticulum (ER) stress, a change in the ER homeostasis, leads to initiation of the unfolded protein response (UPR). The primary functions of the UPR are to restore the ER's …
Deciphering ER stress-unfolded protein response relationship by ...
2024年6月25日 · Here, we report a strategy of visualizing unfolded protein accumulation in the ER lumen in living cells by employing an engineered ER stress sensor, PERK, which forms …
Endoplasmic reticulum stress signals in the tumour and its ... - Nature
2020年11月19日 · In this Review, we discuss the physiological inducers of ER stress in the tumour milieu, the interplay between oncogenic signalling and ER stress response pathways in …
Endoplasmic Reticulum Stress: Signaling the Unfolded Protein Response
Such alterations are referred to as ER stress, and the response activated is the unfolded protein response (UPR). When the UPR is perturbed or not sufficient to deal with the stress …
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