δβ-Thalassemia results from the deletion of both δ and βgenes. Homozygotes for δβ-thalassemia have 100% HbF and, because of the increased synthesis of HbF, may have thalassemia intermedia rather than thalassemia major [1].

Co-inheritance of deletional and non-deletional alpha (alpha) thalassaemias may result in various thalassaemia syndromes. Concomitant co-inheritance with beta (beta) and delta (delta) gene abnormalities would result in improved clinical phenotype.

Thalassemia and the Kleihauer-Betke test. Thalassemia and the Kleihauer-Betke test. Thalassemia and the Kleihauer-Betke test Arch Pathol Lab Med. 1982 Jan;106(1):48-9. Author G Shugar. PMID: 6172090 No abstract available. Publication …

2011年9月14日 · Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of δβ thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto-maternal haemorrhage.

2012年6月1日 · We report here a 33-year-old male patient who was admitted with dengue haemorrhagic fever, with a background history of Grave's disease, incidentally noted to have mild hypochromic microcytic red...

HbF levels 5% and above are more likely to be due to δβ thalassaemia or HPFH (heterocellular or pancellular). In the case of δβ thalassaemia or deletional HPFH one would expect the HbA 2 level to be low. Kleihauer: Red blood cells are stained to detect HbF. This test is used to distinguish heterocellular from pancellular HPFH.

The first Hb analyses in Germany for the detection and identification of anomalous hemoglobin variants and thalassemia syndromes were carried out as early as 1959 in Freiburg by the pediatric hematologist K. Betke and his colleague E. Kleihauer. This was the beginning of a new subspecialty within hematology (5, 16).

Two of 19 transfusion-dependent patients with beta-thalassaemia have been found to have red cells indistinguishable from fetal cells on the basis of HbF content, but these patients also have been found to give positive results by the Kleihauer test.

Kleihauer test negative on normal adult blood. Application: Detection and quantitation of transplacental haemorrhage. Studies in the thalassaemias. See also Flow cytometry (FMH). Interpretation: Volume of transplacental haemorrhage can be estimated from the ratio of fetal (acid resistant) to maternal (ghost) red cells.

A population survey carried out in southern sardinia on more than 5000 people has shown that delta beta (F)-thalassaemia, with a gene frequency of 0-00088, is a rare trait in this population. We examined the members of three families segregating for both delta beta- and beta(0)-thalassemia and a number of delta beta carriers identified during ...