2011年4月14日 · KLOTHO mRNA was restored after treatment with either the DNA demethylating agent 2'-deoxy-5-azacytidine or histone deacetylase inhibitor trichostatin A. Methylation-specific PCR and bisulfite genomic sequencing analysis of the promoter region of KLOTHO revealed CpG hypermethylation in non-KLOTHO-expressing cervical cancer cell lines and in 41% ...

2018年6月7日 · KLOTHO has been identified as having important roles in anti-aging, mineral metabolism, and vitamin D metabolism. A number of studies have indicated that KLOTHO mRNA and protein levels are reduced during acute or chronic kidney diseases in response to high local levels of reactive oxygen species ( 3 ).

2018年6月7日 · Page 1 of 2 - The Klotho Group Buy Thread - posted in Supplements: I would like to pursue a group buy for Klotho, or one of its analogs. I think most of you are aware of how awesome this substance is, so I wont go into that right away. I will say that the group buy will probably be a slow process, as there are a lot of choices to make, and discussions to be had. …

2014年9月12日 · The intelligence boost is so large, that if this new study is right and the effects of klotho are at all acute, you should be able to measure it directly with something like quantified mind or perhaps even just raw introspection. Hopefully lots of researchers follows up on the most obvious implications of these two currently unconnected ...

2018年5月14日 · Exploiting the Gaba > Klotho path - posted in Supplements: MikeDC, in one of the rare moments when he wasnt shilling for Chromadex, alerted me to the following study, and for that I am grateful.

2023年6月5日 · "the elimination of senescent cells leads to a significant increase in the production of a protective protein known as a-klotho. "The senolytic drug dasatinib isn’t available as an over-the-counter drug. But quercetin is available in supplement form. " Interesting no mention of Fisetin/Apigenin. Edited by Gal220, 05 June 2023 - 01:37 AM.

2019年5月1日 · We showed that low-dose fluvastatin and valsartan, separately and in combination, substantially increase expression of SIRT1, PRKAA, and KLOTHO genes, which may be attributed to their so far unreported pleiotropic beneficial effects. This approach could be used for prevention of ageing (and longevity genes)–related disorders.

2021年5月17日 · I agree that he has a pretty heavy "against taking" bias for this or that herb or supplement in general. As far as resveratrol goes, he does present good abstracts that makes a case for NOT taking RES. One of the studies he covers in the vid links resveratrol to kidney failure -although these were not healthy human subjects.

2014年2月15日 · I have looked into Klotho supplementation for a long time. Gaba is the best and only effective way to increase Klotho for healthy old people. Hypertension drugs helps, but you need to have hypertension to take these drugs and they have side effects.

2023年7月21日 · Reviewing What is Known of the Biochemistry of Klotho Relevant to Effects on Life Span - posted in News: Increased klotho expression increases longevity in mice, while reduced klotho expression accelerates aging. The most well studied effects of klotho on organ function involve the kidney and brain, where in both cases it appears protective via a number …