2022年12月23日 · Left ventricular outflow tract obstruction (LVOTO) limits blood flow from the left ventricle. The level of obstruction can be valvular, sub-valvular, or supravalvular. It can include anatomic stenotic lesions anywhere from left ventricle (LV) outflow to descending aorta.

2023年5月18日 · Left ventricular outflow tract obstruction (LVOTO) is a complex dynamic pathology inside the heart which is responsible for significant symptoms such as breathlessness and chest pain on exertion, palpitations, light-headedness and fainting.

2022年5月5日 · Left ventricular outflow tract obstruction (LVOTO) is commonly associated with systolic anterior motion (SAM) of the mitral valve. Congenital heart disease is an important cause in the paediatric population. SAM occurs when “a permissive physiological state arises in an anatomically susceptible heart” (Ibrahim et al, 2012).

2006年11月28日 · Left ventricular outflow tract obstructions (LVOTOs) encompass a series of stenotic lesions starting in the anatomic left ventricular outflow tract (LVOT) and stretching to the descending portion of the aortic arch (Figure 1). Obstruction may be …

2021年11月15日 · LVOTO is caused by fast-flowing blood through the LV outflow tract which pulls the mitral valve anteriorly (towards the LV outflow tract) due to a Venturi effect. This is known as systolic anterior motion (SAM) of the mitral valve.

Left ventricular outflow tract obstruction (LVOTO) is a recognised feature of hypertrophic cardiomyopathy. It is caused by the thickened heart muscle and the abnormal movement of the mitral valve. This is the main mechanism of debilitating symptoms in …

2018年1月16日 · This is systolic anterior motion (SAM) of the leaflet intermittently causing obstruction of the left ventricular outflow tract (LVOT). In general, for any degree of chronic mitral regurgitation leading to pulmonary hypertension, one must focus on the pulmonary vascular resistance (PVR), volume status, and right heart metrics.

2024年7月31日 · Hypertrophic cardiomyopathy (HCM) is a genetically determined disease that commonly results in obstruction of the left ventricular outflow tract (LVOT), which can produce chest discomfort, dyspnea, fatigue, and syncope. This topic discusses the management of patients with HCM and symptoms attributable to LVOT obstruction.

2015年6月30日 · Obstruction of the LVOT is something which can occur dynamically during systole, usually requiring the coexistence of some physiological change and some predisposing anatomic factors. Fixed LVOT obstruction is the logical opposite of …

Left ventricular outflow tract (LVOT) obstruction is a major determinant of heart failure symptoms in obstructive hypertrophic cardiomyopathy (oHCM). Aficamten, a next-in-class cardiac myosin inhibitor, may lower gradients and improve symptoms in these patients.