2018年4月19日 · Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPhos) due to myeloid-specific deletion of CR6-interacting factor 1 (Crif1), an essential …

2020年2月4日 · In M1 macrophages NO is largely the product of inducible nitric oxide synthase (iNOS or Nos2), which, unlike neuronal NOS (nNOS or Nos3) or endothelial NOS (eNOS or …

Using this technique, we demonstrate here that inflammatory M1 macrophages display enhanced glycolytic metabolism and reduced mitochondrial activity. Conversely, anti-inflammatory M2 …

2016年2月16日 · In macrophages, the classical M1 activation program has been noted to rely on glycolysis, while the M2 program seems to require the induction of fatty acid oxidation (FAO) …

Most commonly, monocytes are differentiated over about one week with M-CSF or GM-CSF to produce naive hMDMs (M0) and then polarized into M1 and/or M2 macrophages using stimuli …

The M1-stimulated iμΦ did not display a relevant OCR, similarly to the M1-stimulated BMDMs (Figure 4A,B), which was in line with the notion that under M1 stimulus, macrophages obtain …

2021年11月12日 · Recently, a very novel metabolic-epigenetic link was identified where M1 macrophages were found to use glycolysis for lactate anabolism to generate lactyl-CoA and …

2025年2月25日 · Additionally, the M1 macrophage marker iNOS was significantly down-regulated, ... RAW264.7 mouse macrophage cell line and Madin–Darby canine kidney (MDCK) cell line …

2021年10月31日 · Our study validates the use of this immortalized cell line as a suitable model with which to evaluate in vitro how perturbations can influence the phenotypical and functional …

2025年2月28日 · M1 macrophages promote inflammation, while M2 macrophages reduce inflammation and aid in tissue repair distinguished by the differential expression of diverse …