Development of pyrimidine and purine analogs as potential antineoplastic agents evolved from an early presumption that nucleic acids are involved in growth control. Among the first analogs …

2023年9月1日 · Nucleoside-based drugs, recognized as purine or pyrimidine analogs, have been potent therapeutic agents since their introduction in 1950, deployed widely in the treatment of …

The original syntheses of purine antimetabolites focused on isosteric replacement of oxygen, carbon, or nitrogen in the purine ring, and they were predicated on the same logic as that used …

Pyrimidine analogs include 5-fluorouracil, cytosine arabinoside, 5-azacytidine, and gemcitabine.

The purine analogues used as antineoplastic agents are a group of agents with similar structures, but somewhat different mechanisms of action, pharmacokinetics, indications and adverse …

A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome. A nucleoside metabolic inhibitor indicated to treat different gastrointestinal, including pancreatic …

The development of pyrimidine as well as purine analogs as antineoplastic agents was based on the notion that nucleic acids are essential for the division, growth, and maintenance of the …

2017年4月16日 · The pyrimidine analogues, used as antineoplastic agents, are a diverse group of agents with similar structures but somewhat different mechanisms of action, activities and …

The FDA approved purine and pyrimidine antimetabolites can be grouped into three primary classes (thiopurines, fluoropyrimidines, and the deoxynucleoside analogues) based on …

During the past thirty years, many analogs of naturally occurring purines and pyrimidines have been synthesized and tested for various biological effects [1–6]. A number of these …