2024年11月21日 · Here we present RhoFold+, an RNA language model-based deep learning method that accurately predicts 3D structures of single-chain RNAs from sequences.

This repository contains codes and pre-trained models for RNA foundation model (RNA-FM). RNA-FM outperforms all tested single-sequence RNA language models across a variety of structure prediction tasks as well as several function-related tasks.

2024年11月21日 · We present an RNA language model-based deep learning pipeline for accurate and rapid de novo RNA 3D structure prediction, demonstrating strong accuracy in modeling single-stranded RNAs...

Using an RNA language model (RNA-FM) pretrained on 23,735,169 unannotated RNA sequences and several deep learning modules—including an IPA module that models 3D positions—RhoFold+ can generate valid and largely accurate RNA 3D structures of interest typically within ~0.14 s (without MSA searching). init, initialized; norm, normalize. b, The ...

2023年11月6日 · We presented an RNA MSA-transformer language model (RNA-MSM), based on homologous RNA sequences. RNA-MSM takes the multiple aligned sequences as an input, and outputs corresponding embeddings and attention maps.

2025年2月25日 · RNA, complex compound of high molecular weight that functions in cellular protein synthesis and replaces DNA as a carrier of genetic codes in some viruses. RNA consists of ribose nucleotides and the nitrogenous bases adenine, guanine, cytosine, and uracil.

2024年12月5日 · Leveraging hyperthermophilic RNAs in GARNET and these RNA generative models, we identify mutations in ribosomal RNA that confer increased thermostability to the Escherichia coli ribosome.

In this article, a general approach for predicting three-dimensional (3D) contacts and modeling the architecture of large and structured RNA molecules on the basis of sequence analysis and sequence alignments is described.

2025年2月24日 · Ribonucleic acid, commonly known as RNA, is involved in many biological functions, and some, including gene silencing, are utilized to cure diseases. RNA has recently gained attention as a ...

2024年10月1日 · GenerRNA is pre-trained on large-scale RNA sequences and capable of generating novel RNA sequences with stable secondary structures, while ensuring distinctiveness from existing sequences, thereby expanding our exploration of the RNA space.