2024年2月15日 · The other is known as target discovery – this approach works on the concept that ‘if you want a new drug you must find a new target’, once a target is identified compound libraries are then screened to find a drug that binds to the target and elicits the desired effect.

2023年10月10日 · This paper provides an overview of the current target identification approaches in drug discovery related to experimental biological assays, focusing primarily on affinity-based pull-down and label-free approaches, and discusses their main limitations and advantages.

Target identification is crucial in drug discovery as it involves the characterization of specific molecules or pathways that can be modulated for the synthesis of new drugs or repurposing existing drugs, thereby advancing medicinal chemistry and enhancing the understanding of disease mechanisms.

Target identification is the first step in drug discovery. A target is an entity to which an endogenous ligand or a drug binds resulting in a change in its behavior or function. Enzymes, receptors and transport proteins along with DNA and RNA are the main targets for drugs at the molecular level.

Target-identification and mechanism-of-action studies have important roles in small-molecule probe and drug discovery. Biological and technological advances have resulted in the increasing use of cell-based assays to discover new biologically active small molecules.

4 天之前 · Target identification is a critical first step in the drug discovery process. By identifying and validating the appropriate biological targets, researchers can focus their efforts on developing therapies that can effectively treat diseases.

2022年5月18日 · Target identification is a first and foremost step in drug discovery. It is the process of identifying the direct molecular targets of small molecules, such as nucleic acid and proteins. Target identification can be approached by computational methods, direct biochemical methods, and genetic interactions.

Target identification: Target identification is a preliminary phase of the drug discovery pipeline. In a research trial for the development drug, a clinical investigator needs to be precise with the target thought to drive disease progression to design the drug.

Thorough and intuitive, Target Identification and Validation in Drug Discovery: Methods and Protocols contains a comprehensive list of essential methods and clear protocols to follow.

2013年3月18日 · Target-identification and mechanism-of-action studies have important roles in small-molecule probe and drug discovery. Biological and technological advances have resulted in the...

Identification of the protein targets of hit molecules is essential in the drug discovery process. Target prediction with machine learning algorithms can help accelerate this search, limiting the number of required experiments.

This book explores breakthrough technologies in drug target identification and validation, emphasizing CRISPR-related screening, big data, and in silico approaches, as well as in vivo applications of CRISPR and best uses of animal models in drug development.

2024年7月25日 · In the context of drug screening, target identification helps researchers and pharmaceutical companies understand the underlying mechanisms of a disease and find molecules that can modulate the activity of these targets to treat the condition.

2020年12月22日 · Phenotype-based screening has emerged as an alternative route for discovering new chemical entities toward first-in-class therapeutics. However, clarifying their mode of action has been a significant bottleneck for drug discovery.

2023年10月10日 · Affinity-based pull-down methods use small molecules conjugated with tags to selectively isolate target proteins, while label-free methods utilize small molecules in their natural state to identify targets.

Target identification is a critical first step in the drug discovery process, as it involves identifying molecules (genes, proteins, or other biomolecules) that play a central role in disease mechanisms and can be modulated to produce therapeutic benefits.

Target identification aims to increase the odds of finding a new drug. At this stage, scientists can focus on specific genes, a particular site of the DNA, a protein, or another type of molecule that might be involved in the pathogenesis of the disease …

Big data are used across the whole drug discovery pipeline from target identification and mechanism of action to identification of novel leads and drug candidates. Such methods are depicted and discussed, with the aim to provide a general view of computational tools and databases available.

The accelerated application of AI in DT identification profoundly enhances our understanding of effective therapeutic interactions, and it expedites the entire process from target discovery to drug manufacturing 74. This accelerated AI-driven approach holds immense value for patients by streamlining the development of more targeted therapies.

Hit identification, also known as hit finding or hit discovery, is the process of discovering small drug-like molecules that can potentially bind to a specific biological target. This is a critical early step in the drug discovery process and is the bread and butter of …

This paper provides an overview of the current target identification approaches in drug discovery related to experimental biological assays, focusing primarily on affinity-based pull-down and label-free approaches, and discusses their main limitations and advantages.

Drug discovery, a multifaceted process from compound identification to regulatory approval, historically plagued by inefficiencies and time lags due to limited data utilization, now faces urgent demands for accelerated lead compound identification. Innovations in biological data and computational ch …

Identifying the biological origin of a disease, and the potential targets for intervention, is the first step in the discovery of a medicine. More an art than a science, target identification is grounded in a number of different approaches and technologies, many of which are used in Roche research and early development.

2025年1月31日 · Alzheimer’s disease (AD) is a complex neurodegenerative disorder that currently lacks effective treatment options. This study aimed to identify potential therapeutic targets for the treatment of ...

2025年2月5日 · The identification of multiple allosteric sites on the CB1 receptor and the structural basis for allosteric modulation are emphasized, along with the structure-based discovery of ago-BAMs for CB1 ...

Rapid in silico selection of target focused libraries from commercial repositories is an attractive and cost-effective approach in early drug discovery. If structures of active compounds are available, rapid 2D similarity search can be performed on ...

4 天之前 · This present study explores microbial metabolites as a source of novel anti-cancer agents, leveraging their unique bioactivity and structural diversity, often exhibiting superior target specificity and lower toxicity than synthetic drugs. Through a computational drug discovery pipeline, a large library of 27641 microbial metabolites was ...

Perancangan obat atau desain obat (Drug Design) adalah proses inventif untuk menemukan obat baru berdasarkan pengetahuan tentang obat yang sudah ada atau target biologisnya. [1] Obat umumnya berupa molekul kecil organik yang mengaktifkan atau menghambat fungsi suatu biomolekul seperti protein, yang menghasilkan efek terapeutik.Obat umumnya berupa molekul …