V(D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation.

Recent genomewide analyses of lymphoid neoplasms have revealed V(D)J recombination-driven oncogenic events, and have intensified interest in the regulatory mechanisms responsible for ensuring fidelity during V(D)J recombination.

V(D)J recombination is an essential mechanism of the adaptive immune system, producing a diverse set of antigen receptors in developing lymphocytes via regulated double strand DNA break and subsequent repair.

2002年4月19日 · V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development.

2011年3月11日 · V(D)J recombination, which assembles antigen receptor genes during lymphocyte development, is initiated when the recombination activating gene 1 (RAG1) and RAG2 proteins bind and cleave...

1999年11月18日 · V(D)J recombination is the rearrangement of gene segments that occurs during the maturation of B and T lymphocytes of the immune system, to form the variable regions of immunoglobulin and T-cell antigen receptor genes.

In this review, we summarize the major progress in mechanism studies of immunoglobulin V(D)J gene recombination and CSR as well as SHM, and their regulatory mechanisms. Keywords: B cell; V(D)J recombination; class switch recombination; mechanism; somatic hypermutation.

2014年11月21日 · This section briefly overviews the normal mechanism of V(D)J recombination (for more details, see references 8 and 9). The V(D)J recombinase recognizes conserved DNA sequence elements, termed recombination signal sequences (RSSs), located adjacent to each V, D, and J coding segment.

2024年1月1日 · A series of site-specific recombination events, collectively termed V(D)J recombination, assembles antigen receptor genes from arrays of gene segments (Figure 2.1, Figure 2.2) (for additional reviews on this topic, see Refs.

2004年1月23日 · V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports—the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.