In neurons, action potentials play a central role in cell–cell communication by providing for—or with regard to saltatory conduction, assisting—the propagation of signals along the neuron's axon toward synaptic boutons situated at the ends of an axon; these signals can then connect with other neurons at synapses, or to motor cells or glands.

One recognizable phenotype is that of fast-spiking neurons, which are capable of firing steadily at high frequencies and have narrow action potentials. This phenotype is typical of many...

2023年11月3日 · An action potential is caused by either threshold or suprathreshold stimuli upon a neuron. It consists of three phases: depolarization, overshoot, and repolarization. An action potential propagates along the cell membrane of an axon until it reaches the terminal button.

2012年5月18日 · Synchronous spiking of nearby neurons is the main source of the high-frequency components of the local field. There is a discernable relationship between the temporal evolution of cell...

Spikes are the mechanism that allow neurons to pass information over relatively long distances within themselves. Thus a mechanosensory neuron at the tip of a flipper in a blue whale has to send signals all the way to the spinal cord, and then up the cord to the brainstem.

2023年9月18日 · During an action potential, the recorded waveforms depend on neuronal morphology, spike initiation site, and the relative position of the electrodes and the subcellular compartments 3,4,5,6,7.

2023年11月9日 · Ectopic action potentials (EAPs) were initially observed in pathological conditions including seizures and nerve injury. Several studies have described regular-spiking (RS) pyramidal neurons firing EAPs in seizure models.

In neurons, voltage-gated sodium conductances play an essential role in action potential initiation and propagation (Hodgkin and Huxley, 1952). Voltage-gated sodium channels activate and inactivate within milliseconds.

Neuroscientists often refer to action potentials as ‘spikes’, or say a neuron has ‘fired a spike’ or ‘spiked’. The term is a reference to the shape of an action potential as recorded using sensitive electrical equipment. A neuron spikes when a combination of all the excitation and inhibition it receives makes it reach threshold.

2020年4月27日 · Here we report full-field imaging of cellular deformations accompanying the action potential in mammalian neuron somas (−1.8 to 1.4 nm) and neurites (−0.7 to 0.9 nm), using high-speed quantitative phase imaging with a temporal resolution of 0.1 ms and an optical path length sensitivity of <4 pm per pixel.