One of the most likely targets of ethanol in the central nervous system (CNS) is the GABA A receptor, a member of the ligand-gated ion channel superfamily of receptors. Gamma …

Alcohol alters the balance between γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter, and glutamate, the major excitatory neurotransmitter. Genetic vulnerability to …

GABA as a neurotransmitter has been long known to be affected by alcohol consumption. Recently, two sub types of the GABAA receptor have come into the spotlight for showing what …

2017年9月20日 · We further suggest that the GABA A receptors contributing to alcohol dependence in the rat and presumably in human alcohol use disorders (AUD) are the ethanol …

2006年5月30日 · Thus, the authors provide exciting new evidence for a highly specific interaction of alcohol with a subtype of GABA A receptor that may mediate (at least in part) some of this …

In functional studies, alcohol has been reported to potentiate GABA receptor-mediated 36Cl-flux in microsacs, neurosynaptosomes, and cultured spinal cord neurons at pharmacologically …

2024年10月1日 · Here, we have discovered a transmembrane protein TMEM132B that is a GABA A receptor (GABA A R) auxiliary subunit. Functionally, TMEM132B promotes GABA A R …

2014年8月4日 · It has been recently shown that dihydromyricetin, a flavonoid purified from Hovenia, has unique effects on GABA A receptors and blocks ethanol intoxication and …

Context: Alcohol facilitates gamma-aminobutyric acid (GABA) function, and GABA type A (GABA(A)) receptor-facilitating agents suppress alcohol withdrawal symptoms. Advances in …

Ethanol, the main psychoactive molecule acting in alcoholic beverages, directly impacts the GABAergic system, contributing to GABAergic dysregulations that vary depending on the …