Amyloid-beta precursor protein - Wikipedia
Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor [5] and has been implicated as a regulator of synapse formation, [6] neural plasticity, [7] antimicrobial activity, [8] and iron export. [9]
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
2021年8月30日 · The Aβ is a 4 kDa fragment of the amyloid precursor protein (APP), a larger precursor molecule widely produced by brain neurons, vascular and blood cells (including platelets), and, to a lesser...
Not just amyloid: physiological functions of the amyloid …
2017年3月31日 · Amyloid precursor protein (APP) and the APP-like proteins APLP1 and APLP2 form the mammalian APP gene family. They have important physiological functions in the peripheral and central...
Amyloid precursor protein (APP) and amyloid β (Aβ) interact …
Accumulation and aggregation of neurotoxic amyloid-β (Aβ) peptides generated via amyloidogenic processing of amyloid precursor protein (APP) is considered to play a central role in the disease etiology. APP interacts with cell adhesion molecules, which influence the normal physiological functions of APP, its amyloidogenic and non ...
Amyloid Precursor Protein - an overview | ScienceDirect Topics
Amyloid precursor protein (APP) is a transmembrane protein that is synthesized in the endoplasmic reticulum and plays a major role in synaptic development, mineral transfer, neuronal plasticity, and regulation of cell signaling in neuronal tissues.
Amyloid precursor protein and its interacting proteins in ...
2023年8月3日 · Amyloid precursor protein (APP) is a key molecule in the pathogenesis of Alzheimer's disease (AD) as the pathogenic amyloid-β peptide is derived from it. Two closely related APP family proteins (APPs) have also been identified in mammals.
The amyloid precursor protein: beyond amyloid | Molecular ...
2006年7月3日 · The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD).
Molecular Characteristics of Amyloid Precursor Protein (APP) …
Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are highly conserved in mammals. APP and APLP are known to be intimately ...
Amyloid beta: structure, biology and structure-based …
2017年7月17日 · APP is best known as the precursor molecule cut by β-secretases and γ-secretases to produce a 37 to 49 amino acid residue peptide, Aβ 13, that lies at the heart of the amyloid cascade...
Biology and pathophysiology of the amyloid precursor protein
2011年4月28日 · The amyloid precursor protein (APP) plays a central role in the pathophysiology of Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in the generation of β-amyloid peptides (Aβ).
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