Early embryonic lethality (ie, before and up to mid-gestation) can be straightforward to analyze because the stage at which death occurs suggests why an embryo has failed. Here we …

Early embryonic lethality, i.e. before and up to mid-gestation, can be straightforward to analyze because the stage at which death occurs suggests why an embryo has failed. Here we …

2019年6月28日 · Using the one-step two-cell embryo microinjection (OSTCM) method, we generate viable adult chimeric mice with an embryonically lethal mutation of either Virma or …

2024年8月13日 · In this study, we report the gross embryonic and perinatal phenotypes of 55 lethal strains randomly picked from a collection of mutants that carry piggyBac (PB) …

2011年12月6日 · Using the described basic pathology methods, along with provided histological atlas references and possible 3D imaging techniques, the pathologist can determine …

1997年4月24日 · Inherited mutations in the human BRCA2 gene cause about half of the cases of early-onset breast cancer. The embryonic expression pattern of the mouse Brca2 gene is now …

To study essential maternal gene requirements in the early C. elegans embryo, we have screened for temperature-sensitive, embryonic lethal mutations in an effort to bypass essential zygotic …

2024年12月5日 · In between these extreme cases, for species with more intermediate relatedness, D. albolineatus and D. margaritatus, F1 hybrids exhibit a mixture of lethality at …

2025年2月13日 · Early lethality (embryonic days 9.5-14.5) is almost always associated with severe placental malformations. Placental defects correlate strongly with abnormal brain, heart …

Embryonic and postnatal lethality limited the translational value of many KO mouse lines in the past three decades. The most promising method to rescue a lethal phenotype is the creation …