2024年2月16日 · Graphene oxide nanomaterials are being developed for wide-ranging applications but are associated with potential safety concerns for human health. We conducted a double-blind randomized...

Generally, GFNs may exert different degrees of toxicity in animals or cell models by following with different administration routes and penetrating through physiological barriers, subsequently being distributed in tissues or located in cells, eventually being excreted out of the bodies.

2018年2月24日 · In the absence of mitogens, GONPs stimulated IL-10 synthesis by whole blood cell cultures. The current study shows that GONPs modulate immune system biomarkers and that these may pose a health risk to individuals exposed to this type of nanoparticle.

2016年10月31日 · The lungs are a potential entrance for graphene nanoparticles into the human body through airway. The inhaled GO nanosheets can destroy the ultrastructure and biophysical properties of pulmonary surfactant (PS) film, which is the first line of host defense, and emerge their potential toxicity .

We have previously shown the dose-dependent toxic effects of graphene oxide in a variety of cells, including human breast cancer, ovarian cancer, neuroblastoma, and human lung cancer cells [17,28,31].

ROS can cause some adverse effects, including downregulation of defensive systems to disrupt the structure and function of normal cells, and to cause unbalanced levels of antioxidants. ... Kim J.H. Graphene Oxide-Silver Nanoparticles Nanocomposite Stimulates Differentiation in Human Neuroblastoma Cancer Cells (SH-SY5Y) Int. J. Mol. Sci. 2017;18 ...

2018年9月1日 · An in vitro study of the effects of graphene and graphene oxide on human skin HaCaT keratinocytes demonstrated that oxidized graphene was the most cytotoxic, inducing mitochondrial and plasma-membrane damage, and suggesting low …

2024年4月8日 · A double-blind, randomized, controlled human exposure trial of highly purified and thin nanometre-sized graphene oxide nanosheets shows that acute inhalation of aerosolized nanoparticles is...

2023年5月10日 · Graphene oxide particles at 200 µg/m 3, or filtered air, were inhaled for 2 hours by 14 young healthy volunteers on repeated visits, with measurement of cardiorespiratory parameters before and across 4 hours after exposure. Graphene oxide exposure was well-tolerated with no adverse effects.

2024年4月20日 · GO nanoparticles can induce sustained inflammatory and immunological responses in mouse GNs and cause RBC hemolysis and blood coagulation impairment, suggesting its muscular toxicity and hematotoxicity at high concentrations.