Ketolides are antibiotics belonging to the macrolide group. Ketolides are derived from erythromycin by substituting the cladinose sugar with a keto-group and attaching a cyclic carbamate group in the lactone ring. [1] . These modifications give ketolides much broader spectrum than other macrolides.

Ketolides are a new generation of macrolide antibiotics designed to overcome issues with bacterial resistance to macrolides. They are semi-synthetic antibiotics derived from erythromycin (macrolide antibiotic) and the changes give ketolides a broader spectrum of activity.

Ketolides are a new class of antibacterial drugs (derived from macrolides) designed specifically to fight respiratory tract pathogens that are resistant to macrolides. Ketolides work by inhibiting protein synthesis and blocking the ability of bacteria to make essential proteins required for their maintenance and survival.

Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well as the D-desosamine sugar attached at position 5.

Ketolides are 14-membered macrolides in which the cladinose is replaced by a keto function and which possess in their macrocycle a carbamate linked to an alkyl-aryl extension, represented by telithromycin as the only registered antibiotic. You might find these chapters and articles relevant to …

Ketolides are semisynthetic derivatives of erythromycin A, having a 3-keto function instead of an L -cladinose moiety. These compounds are unable to induce MLSB resistance and are active against inducible erm-containing Gram-positive cocci such as Staphylococcus aureus and Streptococcus pneumoniae.

A Ketolide is a type of antibiotic that targets the 50S subunit of the ribosome, similar to macrolides, and can overcome resistance through mechanisms like ribosomal methylation and partial active efflux.

Ketolides are semi-synthetic macrolide antibiotics with improved activity against several erythromycin-resistant bacterial pathogens.

胺基糖苷类抗生素 （aminoglycoside）是具有 氨基糖 与 氨基环醇 结构的一类 抗生素，在临床主要用于对 革兰氏阴性菌 、 绿脓杆菌 等感染的治疗，1960年代到1970年代曾经非常广泛地使用，但是由于此类药物常有比较严重的 耳毒性 及 肾毒性，使其应用受到一定限制，正在逐渐淡出一线用药的行列。 [1][2] 人类历史上第一个氨基糖苷类抗生素是1940年发现的 链霉素，这一结构系从链霉菌分泌物中分离获得，主要应用于对结核病的治疗。 链霉素有比较严重的耐药性问题， …

Ketolides are a new class of macrolides designed particularly to combat respiratory tract pathogens that have acquired resistance to macrolides. The ketolides are semi-synthetic derivatives of the 14-membered macrolide erythromycin A, and retain the erythromycin macrolactone ring structure as well as the D-desosamine sugar attached at position 5.