Maropitant (INN; [3] brand name: Cerenia, used as maropitant citrate (USAN), is a neurokinin-1 (NK 1) receptor antagonist developed by Zoetis specifically for the treatment of motion …

2009年9月1日 · Maropitant is a highly selective neurokinin 1 (NK1) receptor antagonist that blocks the action of substance P, a key neurotransmitter involved in emesis, in the central nervous …

马罗匹坦能阻断 中枢神经系统 中的 P 物质与受体结合，起到止吐作用。 药动学 以 1mg/kg 剂量给予犬单次皮下注射，生物利用度为 90.7%，与 血浆蛋白 的结合率大于99%。 45min 内可达 …

2024年1月11日 · Examples of NK-1 receptor inhibitors include aprepitant, rolapitant, casopitant, netupitant, maropitant, and fosaprepitant. Rolapitant, a recently developed highly selective NK …

The discovery of antiemetic activity among the first generation antihistamine drugs was serendipitous. Dimenhydrinate (Dramamine) was undergoing evaluation in 1947 as a potential …

We specialize in the identification, isolation, and synthesis of process-related impurities. Our expertise extends to a wide array of impurities, including isomeric impurities, degradation …

2016年2月25日 · Maropitant, used as maropitant citrate, is a neurokinin receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting …

Maropitant (trade name Cerenia in the U.S. and other countries), used as maropitant citrate is a neurokinin (NK1) receptor antagonist, which was developed by Zoetis specifically for the …

Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger …

Maropitant (1.0 mg/kg) was highly effective in preventing motion-induced emesis in cats. These studies indicate that the NK-1 receptor antagonist maropitant is well tolerated, safe and has …