Mitophagy is a selective form of macro-autophagy in which mitochondria are specifically targeted for autophagic degradation. Mitophagy plays an important role in cellular homeostasis by eliminating dysfunctional mitochondria and reducing mitochondrial mass as …

In this review, we compiled current studies investigating the role of BNIP3, DRAM1, and FUNDC1, mediators of receptor-mediated mitophagy, in the progression of preeclampsia and the role of ...

(A) Schematic diagram of mitochondrial fission and fusion. Mitochondria usually take on various forms, and fission usually occurs before mitophagy. Fragmented mitochondria...

2023年11月30日 · We outline mitophagy’s role in specific diseases and describe mitophagy-activating approaches successfully tested in humans, including exercise and nutritional and pharmacological interventions.

The removal of damaged mitochondrial components through a process called mitochondrial autophagy (mitophagy) is essential for the proper function of the mitochondrial network. Hence, mitophagy...

2021年5月16日 · In mammals, the mitophagy pathway involves PTEN-induced putative protein kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin. Learn the role of PINK1, Parkin, and the autophagy machinery in the mitophagy pathway with our interactive pathways and identify key reagents to further your research by reading the pop ups and product tables that ...

Mitophagy is a type of selective autophagy that specifically targets organelles. In previous discussions, we have covered the classification, substrates, and detection of autophagy. Now, we will delve deeper into the classic mechanism and detection methods of mitophagy. ... a. schematic diagram of the probe tracking mechanism. b ...

2018年1月1日 · Mitophagy in yeast (A) Schematic representation of autophagy. When autophagy is induced, isolation membranes nucleate at the preautophagosomal structure/phagophore assembly site (PAS). They grow and engulf cytoplasmic cargos to form a double-membrane vesicle called an autophagosome.

2016年7月25日 · Schematic diagram illustrating the mechanisms and role of mitophagy in disease. PINK1/Parkin-mediated mitophagy promotes the elimination of depolarized mitochondria through the concerted action of PINK1 kinase on ubiquitin and the Parkin E3 ubiquitin ligase, which is recruited by PINK1 to the outer mitochondrial membrane, where it ubiquitinates ...

2011年5月15日 · A schematic illustration of the mitochondrion's life cycle and the roles of mitochondrial dynamics and autophagy in the segregation of dysfunctional mitochondria. The mitochondrion cyclically shifts between a postfusion state (networked) that lasts tens of seconds and a postfission state (solitary) that can last tens of minutes.