Eukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various biological processes. At any given moment, RNAs must accurately navigate the three-dimensional subcellular environment to ensure proper localization and function, governed by numerous factors ...

However, less is known about the subcellular localization and composition of the ribosomes that catalyze and regulate mRNA translation in these compartments, particularly in mammalian cells and specialized cell types. ... 60S, and assembled polysomes at the ER as compared with in the cytosol for cells under different conditions: (D) untreated ...

MiRNA subcellular localizations (MSLs) are essential for uncovering and understanding miRNA functions in various biological processes. Several computational methods have been proposed for measuring MSL. However, existing methods only rely on manually crafted features based on sequence without considering RNA 3D structure information, and most methods often rely on single-model approaches ...

Introduction. The localization of specific RNA molecules to distinct subcellular locations is a widespread phenomenon. In organisms ranging from yeast to human, thousands of different RNA species are asymmetrically localized in a variety of conditions and cell types [].In many cases, the transport of these RNAs is mediated by the interaction of specific cis-localization-regulatory sequences ...

The subcellular localization of proteins plays a critical role in drug discovery and development. Aberrant protein localization has been implicated in various pathological conditions [1], including cancers [2], cardiovascular diseases [3], and neurodegenerative disorders [4].Understanding protein subcellular localization is essential for the identification of therapeutic targets [5], the ...