Mutations in, both, mouse and humans reveal the involvement of several classes of genes in ameloblast life cycle and its function, a process that emerges as a model for elucidating the molecular regulatory cascades that operate in other developmental systems, as well.

Ameloblasts are cells present only during tooth development that deposit tooth enamel, which is the hard outermost layer of the tooth forming the surface of the crown. Each ameloblast is a columnar cell approximately 4 micrometers in diameter, 40 micrometers in length and is hexagonal in cross section.

Fluid phase endocytosis represents an uptake mechanism documented as occurring in ameloblasts. The process of fluid phase endocytosis trafficking of cargo can be demonstrated by supplying exogenously provided horseradish peroxidase (HRP) and observing the intracellular localization of HRP in cell organelles to which HRP is transported.

Each enamel rod follows a retreating Tomes' process from a single ameloblast. At the end of the secretory stage, ameloblasts lose their Tomes' process and produce a thin layer of aprismatic enamel (5).

An ameloblast is a unique cell type responsible for secreting the enamel matrix during tooth development. It is derived from oral ectodermal cells and is the only cell in teeth at birth that originates from the ectoderm.

The differentiation process of epithelial cells is characterized by marked changes in their morphology and polarity, accompanied by dynamic cytoskeletal reorganization and changes in cell–cell and cell–matrix adhesion over time. Functional ameloblasts are tall, columnar, polarized cells that synthesize and secrete enamel-specific proteins.

2012年9月21日 · In this review, we describe how amelogenesis is highly integrated with ameloblast cell activities and how the shape, orientation and organization of enamel mineral ribbons are established by a...

2015年8月12日 · Ameloblast differentiation is the most critical stepwise process in amelogenesis, and it is controlled by precise molecular events. To better understand the mechanism controlling pre-ameloblasts (PABs) differentiation into secretory ameloblasts (SABs), a more precise identification of molecules and signaling networks will elucidate the ...

The ameloblast controls the conformation and vector of movement of the secretory Tomes’ processes, which in turn dictates the orientations of the protein matrix. The behavior of the ameloblast include: ordered secretory events; ameloblast to ameloblast interactions; ameloblast to extracellular matrix interactions; ameloblast to stratum ...

2016年10月16日 · We demonstrate that wild‐type enamel ribbons initiate on dentin mineral on the sides and tips of mineralized collagen fibers, and extend in clusters from dentin to the ameloblast membrane.