Carboplatin is in the platinum-based antineoplastic family of medications and works by interfering with duplication of DNA. [3] [5] Carboplatin was developed as a less toxic analogue of cisplatin. [6] It was patented in 1972 and approved for medical use in 1989. [7] It is on the 2023 World Health Organization's List of Essential Medicines. [8]

Mechanism of action. Carboplatin predominantly acts by attaching alkyl groups to the nucleotides, leading to the formation of monoadducts, and DNA fragmenting when repair enzymes attempt to correct the error. 4,9 2% of carboplatin's activity comes from DNA cross-linking from a base on one strand to a base on another, preventing DNA strands from ...

2023年4月4日 · Carboplatin belongs to a class of medications known as platinum-containing compounds. It works by stopping or slowing the growth of cancer cells. Carboplatin is used in adults in combination with other cancer treatments to treat ovarian cancer .

The platinum-based anti-cancer drugs, including cisplatin 8, carboplatin 9, and oxaliplatin 10, with manifest therapeutic effects and well-defined mechanisms of action, are widely used in the clinic.

Carboplatin is a 'second-generation' platinum compound advocated for use in the treatment of patients with ovarian cancer and it has also shown promise in small cell lung cancer, squamous cell carcinomas of the head and neck, and seminomas.

2012年7月1日 · Carboplatin, a platinum anticancer drug used to treat many types of human cancer, contains a bidentate dicarboxylate chelate leaving ligand, a structural feature that makes it much less chemically reactive than the first-generation platinum anticancer drug cisplatin, which contains two monodentate chloride leaving ligands.

2020年9月15日 · Carboplatin therapy is associated with a low rate of transient serum aminotransferase elevations and with rare instances of clinically apparent liver injury. Carboplatin is an intravenously administered platinum coordination complex and alkylating agent which is used as a chemotherapeutic agent for the treatment of various cancers, mainly ...

The aim of this narrative review was to discuss some of the known molecular mechanisms involved in the absorption, metabolism, detoxification, and resistance to platinum-based drugs, especially carboplatin. MECHANISM OF ACTION. To …

2020年2月17日 · Mechanism of Action. Carboplatin is a platinum compound alkylating agent which covalently binds to DNA; interferes with the function of DNA by producing interstrand DNA cross-links. Carboplatin is apparently not cell-cycle specific. Pharmacokinetics/Pharmacodynamics Distribution

Carboplatin is a cisplatin analogue with a mechanism of action similar to that of alkylating agents. Carboplatin is excreted renally, with 60% to 80% eliminated in the first 24 hours after administration. The platinum from degraded carboplatin binds irreversibly to plasma proteins and is eliminated slowly, with an approximate half-life of 5 ...