Cathepsin D - Wikipedia
Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. [7] The main function of cathepsin D is to degrade proteins and activate precursors of bioactive …
The noncanonical role of the protease cathepsin D as a cofilin ...
2021年1月29日 · Cathepsin D (cathD) is traditionally regarded as a lysosomal protease that degrades substrates in acidic compartments. Here we report cathD plays an unconventional …
The Ins and Outs of Cathepsins - PubMed Central (PMC)
Cathepsin D is known to process vitellogenin and together with B and L, is involved in oogenesis in lower vertebrates. Cathepsins are extensively involved in embryo development.
CATHEPSIN D – MANY FUNCTIONS OF ONE ASPARTIC …
Cathepsin D (CD) is a soluble lysosomal aspartic endopeptidase (EC 3.4.23.5) synthesized in rough endoplasmic reticulum as preprocathepsin D.
CTSD Gene - Cathepsin D
2024年12月24日 · CTSD (Cathepsin D) is a Protein Coding gene. Diseases associated with CTSD include Ceroid Lipofuscinosis, Neuronal, 10 and Neuronal Ceroid Lipofuscinosis . …
Cathepsin D as a potential therapeutic target to enhance ... - Nature
2022年2月4日 · Cathepsin D (Cat D), a protein predominantly localized in lysosomes, performs multiple biological functions, such as degradation of intracellular and extracellular proteins, …
CTSD gene: MedlinePlus Genetics
The CTSD gene provides instructions for making an enzyme called cathepsin D. Cathepsin D is one of a family of cathepsin proteins that act as protease enzymes, which modify proteins by …
Identification of Cathepsin D as a Plasma Biomarker for …
Cathepsin D encoded by the CTSD gene is a lysosomal aspartic acidic protease. It exists as a diglycosylated precursor form (pro-cathepsin D) in the Golgi complex. Once pro-cathepsin D …
Cathepsin D - an overview | ScienceDirect Topics
Cathepsin D is well known to be important for autophagy and apoptosis, and variation in function of cathepsin D likely plays a role in several neurodegenerative disorders, including Alzheimer's …
Cathepsin D overexpression in the nervous system rescues …
2023年7月20日 · Cathepsin D (CTSD) is the principal lysosomal aspartate protease, and is activated in the acidic lysosomal environment 5. In support of a unique role for CTSD, its …