RNA binding protein RALY activates the cholesterol synthesis pathway ...
2022年7月10日 · In this study, we found that RALY can activate the cholesterol synthesis pathway and play its tumor-promoting role by cooperating with SF3B3 in HCC. RALY modulates the …
RNA binding protein RALY activates the cholesterol synthesis pathway ...
2022年7月10日 · RALY acts as a tumor-promoting factor by cooperating with splicing factor 3b subunit 3 (SF3B3) and modulating the splicing switch of Metastasis Associated 1 (MTA1) from …
RALY RALY heterogeneous nuclear ribonucleoprotein [ (human)]
2025年1月4日 · RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma. RNA-binding protein RALY …
RNA结合蛋白RALY通过肝细胞癌中的MTA1剪接开关激活胆固醇合 …
在这里，我们发现与致死黄色蛋白同源物 (RALY) 基因相关的 HnRNP 上调，并与 HCC 患者的不良预后相关。 RALY 通过与剪接因子 3b 亚基 3 (SF3B3) 配合，调节转移相关蛋白 1 (MTA1) …
Collaborative interactions of heterogenous ribonucleoproteins ...
2020年2月20日 · Here, we outline a role for hnRNPs in gene regulatory circuits controlling sterol homeostasis. Specifically, we find that tissue-selective loss of the conserved hnRNP RALY …
The hnRNP RALY regulates transcription and cell proliferation by ...
2017年12月1日 · In a recent study, RALY was found to interact with the long-noncoding RNA LeXis and with promoters of genes involved in the cholesterol biosynthesis pathway in mouse …
Feedback modulation of cholesterol metabolism by LeXis, a lipid ...
2016年6月2日 · LeXis interacts with and affects the DNA interactions of Raly, a heterogeneous ribonucleoprotein that is required for the maximal expression of cholesterologenic genes in …
RNA binding protein RALY activates the cholesterol synthesis pathway ...
2022年4月28日 · RNA binding protein RALY activates the cholesterol synthesis pathway through an MTA1 splicing switch in hepatocellular carcinoma. A novel mechanism by which O …
RNA binding protein RALY activates the cholesterol synthesis pathway ...
2022年4月28日 · Specifically, we find that tissue-selective loss of the conserved hnRNP RALY enriches for metabolic pathways. Liver-specific deletion of RALY alters hepatic lipid content …
lincNORS regulates cholesterol synthesis via interaction with RALY…
In conclusion, our results revealed that the RALY-SF3B3/MTA1/cholesterol synthesis pathway contributes essentially to hepatic carcinogenesis and could serve as a promising therapeutic...
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