2022年12月5日 · In this Review, we describe the major DNA damage checkpoint and repair pathways and discuss the strategies for DDR inactivation using small-molecule inhibitors that are currently being...

2024年11月12日 · Defects in the DNA damage response have been utilized therapeutically for cancer for a decade. This Review analyses the lessons learnt from the development of PARP inhibitors and how these...

2021年7月9日 · In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed, then we summarize the...

Cancer chemotherapy and radiotherapy are designed to cause apoptosis in cancer cells by inducing catastrophic DNA damage such as DSBs. Traditional therapeutic strategies have been developed based on DNA damage response properties of cancer cells that often have specific abnormalities in the pathway .

Over the last decades, the growing understanding on DNA damage response (DDR) pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly clear that the genomic instability of cells resulted from deficient DNA damage response contributes to the occurrence of cancer.

DNA damage induced in cancer cells upon radiation or chemotherapy leads to the release of chromosome fragments or small pieces of DNA that activate an immune response. When DDRi (e.g., PAPRi) are used, more DNA fragments are released, making tumor cells more immunogenic and more sensitive to immunotherapy.

2022年3月7日 · DNA damage response (DDR) pathways encompass a variety of mechanisms that cells employ in response to DNA damage. While DDR promotes genomic stability in normal cells, it also protects cancer cells from DNA lesions, particularly against exogenous DNA-damaging agents.

2023年11月2日 · Defects in the DNA damage response pathways can give rise to various diseases, including cancer. The DNA damage response (DDR) system is instrumental in safeguarding genomic stability. The accumulation of DNA damage and the weakening of DDR function both promote the initiation and progression of tumors.

2012年1月18日 · A better understanding of the cellular response to DNA damage will not only inform our knowledge of cancer development but also help to refine the classification as well as the treatment of the disease.

Almost invariably, cervical carcinogenesis involves infection with the human papillomavirus (HPV), which inactivates part of the DNA damage response. This HPV-mediated partial inactivation of the DDR presents therapeutic targeting of the residual DDR as an interesting approach to achieve chemoradio-sensitization for cervical cancer.