2023年6月21日 · Lipid nanoparticles (LNPs) are manufactured by combining lipids, therapeutic agents, and solvents (e.g. ethanol) in a process that includes nano-precipitation, extrusion, dilution, high-pressure homogenization, or sonication.

The process involves dissolving lipids in organic solvents, creating a thin lipid film via solvent evaporation, and hydrating it with an aqueous solution to trigger nanoparticle formation.

2023年10月17日 · Helix Biotech’s Nova™ Benchtop (BT) system is a NP manufacturing system which employs impinging jet mixers for rapid nanoprecipitation. Researchers can quickly screen and optimize lipid, polymer, or hybrid nanoparticle formulations, while maintaining a path for upscaling in the future.

2023年6月8日 · Lipid nanoparticles (LNPs), composed of lipids and encapsulating active pharmaceutical ingredients (APIs), have gained considerable attention due to their ability to overcome bioavailability and stability limitations associated with traditional drug delivery methods.

Development and manufacturing of Lb-NP products often involves complex processes that need to be thoroughly understood and controlled to ensure optimum and constant quality of the medicine for patients.

Lipid nanoparticle (LNP) formulations are often manufactured by rapid mixing. Read on to explore LNP formulation methods and the LNP manufacturing process.

Microfluidizer ® Technology provides a scalable solution for the Lipid Nanoparticles (LNPs) manufacturing process. LNPs, including various lipid-based platforms such as liposomes, nanostructured lipid carriers (NLCs), and solid lipid nanoparticles (SLNs), are critical for the delivery of protein and amino acid-type antigens.

2024年9月23日 · In this study, adjustments to aqueous to lipid phase ratios were assessed for their impact on LNP size and other critical quality attributes (CQAs). It was observed that minor adjustments of aqueous-to-organic lipid phase ratios can be used to precisely control the size of ALC-0315-formulated LNPs.

2021年8月10日 · MICROFLUIDIC GENERATION OF NANOPARTICLES. In microfluidic systems, nanoparticles are generated at the interface of two flows, frequently a lipid – which forms the particle – dissolved in an organic solvent (such as ethanol) and a hydrophilic cargo or drug dissolved in water or an aqueous buffer.

The typical manufacturing process for liposome formulations is comprised of four steps that can be summarised as: formation, size reduction, purification and sterile filtration.